Parahydrogen-induced polarization in imaging: Subsecond13C angiography
نویسندگان
چکیده
منابع مشابه
Parahydrogen-induced polarization at zero magnetic field.
We use symmetry arguments and simple model systems to describe the conversion of the singlet state of parahydrogen into an oscillating sample magnetization at zero magnetic field. During an initial period of free evolution governed by the scalar-coupling Hamiltonian HJ, the singlet state is converted into scalar spin order involving spins throughout the molecule. A short dc pulse along the z ax...
متن کاملTransfer of Parahydrogen-Induced Polarization to 19F:
Introduction Parahydrogen-Induced Polarization (PHIP) leads to strong signal enhancement in H-NMR if unsaturated substrates are hydrogenated with parahydrogen (p-H2) applying an appropriate catalyst. As shown before, this polarization can be transferred to heteronuclei such as C. For imaging the lung, a F-hyperpolarized contrast agent should be available, if possible for inhalation. Normally, t...
متن کاملParahydrogen Induced polarization by homogeneous catalysis: theory and applications.
The alignment of the nuclear spins in parahydrogen can be transferred to other molecules by a homogeneously catalyzed hydrogenation reaction resulting in dramatically enhanced NMR signals. In this chapter we introduce the involved theoretical concepts by two different approaches: the well known, intuitive population approach and the more complex but more complete density operator formalism. Fur...
متن کاملParahydrogen induced polarization of barbituric acid derivatives: 1H hyperpolarization studies.
Homogeneous hydrogenation of barbituric acid derivatives with parahydrogen yields a substantial increase of the (1)H NMR signals of the reaction products. These physiologically relevant compounds were hydrogenated at both ambient and elevated temperatures and pressures using a standard cationic rhodium catalyst. The resulting nonthermal nuclear spin polarization (hyperpolarization) is limited b...
متن کاملParahydrogen Induced Polarization of 1-13C-Phospholactate-d2 for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d2, precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d2, is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d2 was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2001
ISSN: 0740-3194
DOI: 10.1002/mrm.1152